Ontology highlight
ABSTRACT:
SUBMITTER: Cierlitza M
PROVIDER: S-EPMC4335723 | biostudies-literature | 2015 Feb
REPOSITORIES: biostudies-literature
Cierlitza Monika M Chauvistré Heike H Bogeski Ivan I Zhang Xin X Hauschild Axel A Herlyn Meenhard M Schadendorf Dirk D Vogt Thomas T Roesch Alexander A
Experimental dermatology 20150201 2
Despite recent success in melanoma therapy, most patients with metastatic disease still undergo deadly progression. We have identified a novel mechanism of multidrug resistance allowing a small subpopulation of slow-cycling melanoma cells to survive based on elevated oxidative bioenergy metabolism. In this study, we asked whether such slow-cycling cells could be eliminated by co-treatment with the copper-chelator elesclomol. Elesclomol-copper complexes can cause oxidative stress by disruption of ...[more]