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Novel conjugative plasmid from Escherichia coli of swine origin that coharbors the multiresistance gene cfr and the extended-spectrum-?-lactamase gene blaCTX-M-14b.


ABSTRACT: Two porcine Escherichia coli isolates harbored the cfr gene on conjugative plasmids of 38,405 bp (pGXEC6) and 41,646 bp (pGXEC3). In these two plasmids, the cfr gene was located within a 4,612-bp region containing a tnpA-IS26-cfr-IS26-?hyp element. Plasmid pGXEC3 was almost identical to pGXEC6 except for a 3,235-bp ISEcp1-blaCTX-M-14b insertion. The colocation of the multiresistance cfr gene with an extended-spectrum-?-lactamase gene on a conjugative plasmid may support the dissemination of these genes by coselection.

SUBMITTER: Zhang WJ 

PROVIDER: S-EPMC4335840 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature

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Novel conjugative plasmid from Escherichia coli of swine origin that coharbors the multiresistance gene cfr and the extended-spectrum-β-lactamase gene blaCTX-M-14b.

Zhang Wan-Jiang WJ   Wang Xiu-Mei XM   Dai Lei L   Hua Xin X   Dong Zhimin Z   Schwarz Stefan S   Liu Siguo S  

Antimicrobial agents and chemotherapy 20141124 2


Two porcine Escherichia coli isolates harbored the cfr gene on conjugative plasmids of 38,405 bp (pGXEC6) and 41,646 bp (pGXEC3). In these two plasmids, the cfr gene was located within a 4,612-bp region containing a tnpA-IS26-cfr-IS26-Δhyp element. Plasmid pGXEC3 was almost identical to pGXEC6 except for a 3,235-bp ISEcp1-blaCTX-M-14b insertion. The colocation of the multiresistance cfr gene with an extended-spectrum-β-lactamase gene on a conjugative plasmid may support the dissemination of thes  ...[more]

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