Engineered cationic antimicrobial peptides to overcome multidrug resistance by ESKAPE pathogens.
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ABSTRACT:
SUBMITTER: Deslouches B
PROVIDER: S-EPMC4335883 | biostudies-literature | 2015 Feb
REPOSITORIES: biostudies-literature
Publications
Engineered cationic antimicrobial peptides to overcome multidrug resistance by ESKAPE pathogens.
Deslouches Berthony B Steckbeck Jonathan D JD Craigo Jodi K JK Doi Yohei Y Burns Jane L JL Montelaro Ronald C RC
Antimicrobial agents and chemotherapy 20141124 2
Multidrug resistance constitutes a threat to the medical achievements of the last 50 years. In this study, we demonstrated the abilities of two de novo engineered cationic antibiotic peptides (eCAPs), WLBU2 and WR12, to overcome resistance from 142 clinical isolates representing the most common multidrug-resistant (MDR) pathogens and to display a lower propensity to select for resistant bacteria in vitro compared to that with colistin and LL37. The results warrant an exploration of eCAPs for use ...[more]
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