Ontology highlight
ABSTRACT:
SUBMITTER: Koussa MA
PROVIDER: S-EPMC4336243 | biostudies-literature | 2015 Feb
REPOSITORIES: biostudies-literature
Nature methods 20141208 2
We introduce a nanoscale experimental platform that enables kinetic and equilibrium measurements of a wide range of molecular interactions using a gel electrophoresis readout. Programmable, self-assembled DNA nanoswitches serve both as templates for positioning molecules and as sensitive, quantitative reporters of molecular association and dissociation. We demonstrated this low-cost, versatile, 'lab-on-a-molecule' system by characterizing ten different interactions, including a complex four-body ...[more]