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Age- and gender-dependent heterogeneous proportion of variation explained by SNPs in quantitative traits reflecting human health.

ABSTRACT: Age-related effects are often included as covariates in the analytical model for genome-wide association analysis of quantitative traits reflecting human health. Nevertheless, previous studies have hardly examined the effects of age on the proportion of variation explained by single nucleotide polymorphisms (PVSNP) in these traits. In this study, the PVSNP estimates of body mass index (BMI), waist-to-hip ratio, pulse pressure, high-density lipoprotein cholesterol level, triglyceride level (TG), low-density lipoprotein cholesterol level, and glucose level were obtained from Korean consortium metadata partitioned by gender or by age. Restricted maximum likelihood estimates of the PVSNP were obtained in a mixed model framework. Previous studies using pedigree data suggested possible differential heritability of certain traits with regard to gender, which we observed in our current study (BMI and TG; P?

SUBMITTER: Lee D

PROVIDER: S-EPMC4336297 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature

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Age- and gender-dependent heterogeneous proportion of variation explained by SNPs in quantitative traits reflecting human health.

Lee Dain D Lee Chaeyoung C

Age (Dordrecht, Netherlands) 20150221 2

Age-related effects are often included as covariates in the analytical model for genome-wide association analysis of quantitative traits reflecting human health. Nevertheless, previous studies have hardly examined the effects of age on the proportion of variation explained by single nucleotide polymorphisms (PVSNP) in these traits. In this study, the PVSNP estimates of body mass index (BMI), waist-to-hip ratio, pulse pressure, high-density lipoprotein cholesterol level, triglyceride level (TG), ...[more]

PMID: 25701395

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