Insight into the role of alternative splicing within the RBM10v1 exon 10 tandem donor site.

ABSTRACT:

Background

RBM10 is an RNA binding protein involved in the regulation of transcription, alternative splicing and message stabilization. Mutations in RBM10, which maps to the X chromosome, are associated with TARP syndrome, lung and pancreatic cancers. Two predominant isoforms of RBM10 exist, RBM10v1 and RBM10v2. Both variants have alternate isoforms that differ by one valine residue, at amino acid 354 (RBM10v1) or 277 (RBM10v2). It was recently observed that a novel point mutation at amino acid 354 of RBM10v1, replacing valine with glutamic acid, correlated with preferential expression of an exon 11 inclusion variant of the proliferation regulatory protein NUMB, which is upregulated in lung cancer.

Findings

We demonstrate, using the GLC20 male-derived small cell lung cancer

SUBMITTER: Tessier SJ 

PROVIDER: S-EPMC4336493 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature