CIAPIN1 and ABCA13 are markers of poor survival in metastatic ovarian serous carcinoma.

ABSTRACT:

Background

The objective of this study was to investigate the expression and clinical role of 14 genes previously shown to be associated with chemotherapy response and/or progression-free survival in a smaller series of ovarian serous carcinoma effusions.

Methods

Advanced-stage serous ovarian carcinoma effusions (n = 150) were analyzed for mRNA expression of AKR1C1, ABCA4, ABCA13, ABCB10, BIRC6, CASP9, CIAPIN1, FAS, MGMT, MUTYH, POLH, SRC, TBRKB and XPA using quantitative real-time PCR. mRNA expression was studied for association with clinicopathologic parameters, including chemotherapy response and survival.

Results

ABCA4 mRNA expression was significantly related to better (complete) chemotherapy response at diagnosis in the entire cohort (p = 0.018), whereas higher

SUBMITTER: Nymoen DA 

PROVIDER: S-EPMC4336750 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature