Ontology highlight
ABSTRACT:
SUBMITTER: Blum ID
PROVIDER: S-EPMC4337656 | biostudies-literature | 2014 Dec
REPOSITORIES: biostudies-literature
Blum Ian D ID Zhu Lei L Moquin Luc L Kokoeva Maia V MV Gratton Alain A Giros Bruno B Storch Kai-Florian KF
eLife 20141229
Ultradian (~4 hr) rhythms in locomotor activity that do not depend on the master circadian pacemaker in the suprachiasmatic nucleus have been observed across mammalian species, however, the underlying mechanisms driving these rhythms are unknown. We show that disruption of the dopamine transporter gene lengthens the period of ultradian locomotor rhythms in mice. Period lengthening also results from chemogenetic activation of midbrain dopamine neurons and psychostimulant treatment, while the anti ...[more]