Unknown

Dataset Information

0

Defective natural killer cell anti-viral capacity in paediatric HBV infection.


ABSTRACT: Natural killer (NK) cells exhibit dysregulated effector function in adult chronic hepatitis B virus (HBV) infection (CHB), which may contribute to virus persistence. The role of NK cells in children infected perinatally with HBV is less studied. Access to a unique cohort enabled the cross-sectional evaluation of NK cell frequency, phenotype and function in HBV-infected children relative to uninfected children. We observed a selective defect in NK cell interferon (IFN)-? production, with conserved cytolytic function, mirroring the functional dichotomy observed in adult infection. Reduced expression of NKp30 on NK cells suggests a role of impaired NK-dendritic cell (DC) cellular interactions as a potential mechanism leading to reduced IFN-? production. The finding that NK cells are already defective in paediatric CHB, albeit less extensively than in adult CHB, has potential implications for the timing of anti-viral therapy aiming to restore immune control.

SUBMITTER: Heiberg IL 

PROVIDER: S-EPMC4337679 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature

altmetric image

Publications

Defective natural killer cell anti-viral capacity in paediatric HBV infection.

Heiberg I L IL   Pallett L J LJ   Winther T N TN   Høgh B B   Maini M K MK   Peppa D D  

Clinical and experimental immunology 20150301 3


Natural killer (NK) cells exhibit dysregulated effector function in adult chronic hepatitis B virus (HBV) infection (CHB), which may contribute to virus persistence. The role of NK cells in children infected perinatally with HBV is less studied. Access to a unique cohort enabled the cross-sectional evaluation of NK cell frequency, phenotype and function in HBV-infected children relative to uninfected children. We observed a selective defect in NK cell interferon (IFN)-γ production, with conserve  ...[more]

Similar Datasets

| S-EPMC7458139 | biostudies-literature
| S-EPMC8221253 | biostudies-literature
2023-10-27 | GSE236822 | GEO
2024-08-01 | GSE241183 | GEO
| S-EPMC5276800 | biostudies-literature
| S-EPMC3637707 | biostudies-literature
2023-10-27 | GSE236820 | GEO
2023-10-27 | GSE236819 | GEO
| S-EPMC3538256 | biostudies-literature
| S-EPMC5988867 | biostudies-literature