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Defective natural killer cell anti-viral capacity in paediatric HBV infection.

ABSTRACT: Natural killer (NK) cells exhibit dysregulated effector function in adult chronic hepatitis B virus (HBV) infection (CHB), which may contribute to virus persistence. The role of NK cells in children infected perinatally with HBV is less studied. Access to a unique cohort enabled the cross-sectional evaluation of NK cell frequency, phenotype and function in HBV-infected children relative to uninfected children. We observed a selective defect in NK cell interferon (IFN)-? production, with conserved cytolytic function, mirroring the functional dichotomy observed in adult infection. Reduced expression of NKp30 on NK cells suggests a role of impaired NK-dendritic cell (DC) cellular interactions as a potential mechanism leading to reduced IFN-? production. The finding that NK cells are already defective in paediatric CHB, albeit less extensively than in adult CHB, has potential implications for the timing of anti-viral therapy aiming to restore immune control.

SUBMITTER: Heiberg IL

PROVIDER: S-EPMC4337679 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature

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Defective natural killer cell anti-viral capacity in paediatric HBV infection.

Heiberg I L IL Pallett L J LJ Winther T N TN Høgh B B Maini M K MK Peppa D D

Clinical and experimental immunology 20150301 3

Natural killer (NK) cells exhibit dysregulated effector function in adult chronic hepatitis B virus (HBV) infection (CHB), which may contribute to virus persistence. The role of NK cells in children infected perinatally with HBV is less studied. Access to a unique cohort enabled the cross-sectional evaluation of NK cell frequency, phenotype and function in HBV-infected children relative to uninfected children. We observed a selective defect in NK cell interferon (IFN)-γ production, with conserve ...[more]

PMID: 25311087

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Project description:This SuperSeries is composed of the SubSeries listed below.

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