Ontology highlight
ABSTRACT:
SUBMITTER: Heiberg IL
PROVIDER: S-EPMC4337679 | biostudies-literature | 2015 Mar
REPOSITORIES: biostudies-literature
Heiberg I L IL Pallett L J LJ Winther T N TN Høgh B B Maini M K MK Peppa D D
Clinical and experimental immunology 20150301 3
Natural killer (NK) cells exhibit dysregulated effector function in adult chronic hepatitis B virus (HBV) infection (CHB), which may contribute to virus persistence. The role of NK cells in children infected perinatally with HBV is less studied. Access to a unique cohort enabled the cross-sectional evaluation of NK cell frequency, phenotype and function in HBV-infected children relative to uninfected children. We observed a selective defect in NK cell interferon (IFN)-γ production, with conserve ...[more]