Ontology highlight
ABSTRACT:
SUBMITTER: Finney OC
PROVIDER: S-EPMC4337823 | biostudies-literature | 2014 Apr
REPOSITORIES: biostudies-literature
Finney Olivia C OC Keitany Gladys J GJ Smithers Hannah H Kaushansky Alexis A Kappe Stefan S Wang Ruobing R
Vaccine 20140228 19
Whole-parasite malaria vaccines have shown promise in clinical trials. We recently reported the first human trial of a malaria vaccine based on Plasmodium falciparum genetically attenuated parasites (PfGAP). Herein we report for the first time that PfGAP induces prolonged functional humoral responses in humans. Six volunteers were exposed to 5 bites of PfGAP-infected mosquitoes followed by approximately 200 bites. Plasma collected from all volunteers 3 months after the last exposure efficiently ...[more]