Ontology highlight
ABSTRACT:
SUBMITTER: Rodon J
PROVIDER: S-EPMC4337847 | biostudies-literature | 2015 Feb
REPOSITORIES: biostudies-literature
Rodon Jordi J Carducci Michael A MA Sepulveda-Sánchez Juan M JM Azaro Analia A Calvo Emiliano E Seoane Joan J Braña Irene I Sicart Elisabet E Gueorguieva Ivelina I Cleverly Ann L AL Pillay N Sokalingum NS Desaiah Durisala D Estrem Shawn T ST Paz-Ares Luis L Holdhoff Matthias M Blakeley Jaishri J Lahn Michael M MM Baselga Jose J
Clinical cancer research : an official journal of the American Association for Cancer Research 20141125 3
<h4>Purpose</h4>TGFβ signaling plays a key role in tumor progression, including malignant glioma. Small-molecule inhibitors such as LY2157299 monohydrate (LY2157299) block TGFβ signaling and reduce tumor progression in preclinical models. To use LY2157299 in the treatment of malignancies, we investigated its properties in a first-in-human dose (FHD) study in patients with cancer.<h4>Experimental design</h4>Sixty-five patients (58 with glioma) with measurable and progressive malignancies were enr ...[more]