Dataset Information

Cut-off value of total adiponectin for managing risk of developing metabolic syndrome in male Japanese workers.

ABSTRACT: To determine the optimal cut-off value of serum total adiponectin for managing the risk of developing metabolic syndrome (MetS) in male Japanese workers.A total of 365 subjects without MetS aged 20-60 years were followed up prospectively for a mean of 3.1 years. The accelerated failure-time model was used to estimate time ratio (TR) and cut-off value for developing MetS.During follow-up, 45 subjects developed MetS. Age-adjusted TR significantly declined with decreasing total adiponectin level (? 4.9, 5.0-6.6, 6.7-8.8 and ? 8.9 ?g/ml, P for trend = 0.003). In multivariate analyses, TR of MetS was 0.12 (95% CI 0.02-0.78; P = 0.03) in subjects with total adiponectin level of 5.0-6.6 ?g/ml, and 0.15 (95% CI 0.02-0.97; P = 0.047) in subjects with total adiponectin level ? 4.9 ?g/ml compared with those with total adiponectin level ? 8.9 ?g/ml. The accelerated failure-time model showed that the optimal cut-off value of total adiponectin for managing the risk of developing MetS was 6.2 ?g/ml. In the multivariate-adjusted model, the mean time to the development of MetS was 78% shorter for total adiponectin level ? 6.2 ?g/ml compared with > 6.2 ?g/ml (TR 0.22, 95% CI: 0.08-0.64, P = 0.005).Our findings suggest that the cut-off value for managing the risk of developing MetS is 6.2 ?g/ml in male Japanese workers. Subjects with total adiponectin level ? 6.2 ?g/ml developed MetS more rapidly than did those with total adiponectin level > 6.2 ?g/ml.

SUBMITTER: Hata A

PROVIDER: S-EPMC4337907 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature

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Cut-off value of total adiponectin for managing risk of developing metabolic syndrome in male Japanese workers.

Hata Akiko A Yonemoto Koji K Shikama Yosuke Y Aki Nanako N Kosugi Chisato C Tamura Ayako A Ichihara Takako T Minagawa Takako T Kuwamura Yumi Y Miyoshi Masashi M Nakao Takayuki T Funaki Makoto M

PloS one 20150223 2

<h4>Aim</h4>To determine the optimal cut-off value of serum total adiponectin for managing the risk of developing metabolic syndrome (MetS) in male Japanese workers.<h4>Methods</h4>A total of 365 subjects without MetS aged 20-60 years were followed up prospectively for a mean of 3.1 years. The accelerated failure-time model was used to estimate time ratio (TR) and cut-off value for developing MetS.<h4>Results</h4>During follow-up, 45 subjects developed MetS. Age-adjusted TR significantly decline ...[more]

PMID: 25705909

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Project description:BackgroundMetabolic syndrome (MetS) is associated with cancer risk; however, little is known regarding its relationship with the risk of cancer-related premature death and long-term sick leave (LTSL), which can lead to a substantial loss in working years. The present study aimed to quantify the all-site and site-specific associations between MetS and the risk of severe cancer events (a composite outcome of LTSL and mortality due to cancer) in a large working population in Japan.MethodsWe recruited 70,875 workers (59,950 men and 10,925 women), aged 20-59 years, who attended health check-ups in 2011 (10 companies) and 2014 (2 companies). All workers underwent follow up for severe cancer events until March 31, 2020. MetS was defined in accordance with the Joint Interim Statement. Cox regression models were used to quantify the association between baseline MetS and severe cancer events.ResultsDuring 427,379 person-years of follow-up, 523 participants experienced the outcome consisting of 493 LTSLs of which 124 eventually resulted in death, and 30 deaths without taking LTSL. The adjusted hazard ratios (HR) (95% confidence intervals [CI]) for composite severe events due to all-site, obesity-related, and non-obesity-related cancer among those with vs. without MetS were 1.26 (1.03, 1.55), 1.37 (1.04, 1.82), and 1.15 (0.84, 1.56), respectively. In cancer site-specific analyses, MetS was associated with an increased risk of severe events due to pancreatic cancer (HR, 2.06; 95% CI, 0.99-4.26). When mortality was treated solely as the endpoint, the association was significant for all-site (HR, 1.58; 95% CI, 1.10-2.26), and obesity-related (HR, 1.59; 95% CI, 1.00-2.54) cancer. Additionally, a greater number of MetS components was associated with a greater risk of both severe cancer events and cancer-related mortality (P trend < 0.05).ConclusionAmong Japanese workers, MetS was associated with an increased risk of severe cancer events, especially those due to obesity-linked cancer.

Dataset Information

Cut-off value of total adiponectin for managing risk of developing metabolic syndrome in male Japanese workers.

Publications

Cut-off value of total adiponectin for managing risk of developing metabolic syndrome in male Japanese workers.

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