Ontology highlight
ABSTRACT:
SUBMITTER: Deidda G
PROVIDER: S-EPMC4338533 | biostudies-literature | 2015 Jan
REPOSITORIES: biostudies-literature
Deidda Gabriele G Allegra Manuela M Cerri Chiara C Naskar Shovan S Naskar Shovan S Bony Guillaume G Zunino Giulia G Bozzi Yuri Y Caleo Matteo M Cancedda Laura L
Nature neuroscience 20141208 1
Hyperpolarizing and inhibitory GABA regulates critical periods for plasticity in sensory cortices. Here we examine the role of early, depolarizing GABA in the control of plasticity mechanisms. We report that brief interference with depolarizing GABA during early development prolonged critical-period plasticity in visual cortical circuits without affecting the overall development of the visual system. The effects on plasticity were accompanied by dampened inhibitory neurotransmission, downregulat ...[more]