Ontology highlight
ABSTRACT:
SUBMITTER: Mele V
PROVIDER: S-EPMC4338537 | biostudies-literature | 2014 Jun
REPOSITORIES: biostudies-literature
Mele Valentina V Muraro Manuele G MG Calabrese Diego D Pfaff Dennis D Amatruda Nunzia N Amicarella Francesca F Kvinlaug Brynn B Bocelli-Tyndall Chiara C Martin Ivan I Resink Therese J TJ Heberer Michael M Oertli Daniel D Terracciano Luigi L Spagnoli Giulio C GC Iezzi Giandomenica G
International journal of cancer 20140130 11
Mesenchymal stem/stromal cells (MSC) are multipotent precursors endowed with the ability to home to primary and metastatic tumor sites, where they can integrate into the tumor-associated stroma. However, molecular mechanisms and outcome of their interaction with cancer cells have not been fully clarified. In this study, we investigated the effects mediated by bone marrow-derived MSC on human colorectal cancer (CRC) cells in vitro and in vivo. We found that MSC triggered epithelial-to-mesenchymal ...[more]