Network analysis of circular permutations in multidomain proteins reveals functional linkages for uncharacterized proteins.
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ABSTRACT:
SUBMITTER: Adjeroh D
PROVIDER: S-EPMC4338801 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
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Network analysis of circular permutations in multidomain proteins reveals functional linkages for uncharacterized proteins.
Adjeroh Donald D Jiang Yue Y Jiang Bing-Hua BH Lin Jie J
Cancer informatics 20140101 Suppl 5
Various studies have implicated different multidomain proteins in cancer. However, there has been little or no detailed study on the role of circular multidomain proteins in the general problem of cancer or on specific cancer types. This work represents an initial attempt at investigating the potential for predicting linkages between known cancer-associated proteins with uncharacterized or hypothetical multidomain proteins, based primarily on circular permutation (CP) relationships. First, we pr ...[more]
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