Ontology highlight
ABSTRACT:
SUBMITTER: Chao YC
PROVIDER: S-EPMC4339118 | biostudies-literature | 2015 Feb
REPOSITORIES: biostudies-literature
Chao Ying-Chi YC Chen Chih-Cheng CC Lin Yuh-Charn YC Breer Heinz H Fleischer Joerg J Yang Ruey-Bing RB
The EMBO journal 20141201 3
Transmembrane guanylyl cyclases (GCs), with activity regulated by peptide ligands and/or calcium-binding proteins, are essential for various physiological and sensory processes. The mode of activation of the GC subtype GC-G, which is expressed in neurons of the Grueneberg ganglion that respond to cool temperatures, has been elusive. In searching for appropriate stimuli to activate GC-G, we found that its enzymatic activity is directly stimulated by cool temperatures. In this context, it was obse ...[more]