Ontology highlight
ABSTRACT:
SUBMITTER: Williams JD
PROVIDER: S-EPMC4339527 | biostudies-literature | 2015 Mar
REPOSITORIES: biostudies-literature
Williams John D JD Torhan Matthew C MC Neelagiri Venugopal R VR Brown Carson C Bowlin Nicholas O NO Di Ming M McCarthy Courtney T CT Aiello Daniel D Peet Norton P NP Bowlin Terry L TL Moir Donald T DT
Bioorganic & medicinal chemistry 20150113 5
The increasing prevalence of drug-resistant bacterial infections is driving the discovery and development not only of new antibiotics, but also of inhibitors of virulence factors that are crucial for in vivo pathogenicity. One such virulence factor is the type III secretion system (T3SS), which plays a critical role in the establishment and dissemination of Pseudomonas aeruginosa infections. We have recently described the discovery and characterization of a series of inhibitors of P. aeruginosa ...[more]