Total and cause-specific mortality of U.S. nurses working rotating night shifts.

ABSTRACT:

Background

Rotating night shift work imposes circadian strain and is linked to the risk of several chronic diseases.

Purpose

To examine associations between rotating night shift work and all-cause; cardiovascular disease (CVD); and cancer mortality in a prospective cohort study of 74,862 registered U.S. nurses from the Nurses' Health Study.

Methods

Lifetime rotating night shift work (defined as ≥3 nights/month) information was collected in 1988. During 22 years (1988-2010) of follow-up, 14,181 deaths were documented, including 3,062 CVD and 5,413 cancer deaths. Cox proportional hazards models estimated multivariable-adjusted hazard ratios (HRs) and 95% CIs.

Results

All-cause and CVD mortality were significantly increased among women with ≥5 years of rotating ni

SUBMITTER: Gu F 

PROVIDER: S-EPMC4339532 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature