2- and 3-substituted imidazo[1,2-a]pyrazines as inhibitors of bacterial type IV secretion.
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ABSTRACT:
SUBMITTER: Sayer JR
PROVIDER: S-EPMC4339681 | biostudies-literature | 2014 Nov
REPOSITORIES: biostudies-literature
Publications
2- and 3-substituted imidazo[1,2-a]pyrazines as inhibitors of bacterial type IV secretion.
Sayer James R JR Walldén Karin K Pesnot Thomas T Campbell Frederick F Gane Paul J PJ Simone Michela M Koss Hans H Buelens Floris F Boyle Timothy P TP Selwood David L DL Waksman Gabriel G Tabor Alethea B AB
Bioorganic & medicinal chemistry 20140928 22
A novel series of 8-amino imidazo[1,2-a]pyrazine derivatives has been developed as inhibitors of the VirB11 ATPase HP0525, a key component of the bacterial type IV secretion system. A flexible synthetic route to both 2- and 3-aryl substituted regioisomers has been developed. The resulting series of imidazo[1,2-a]pyrazines has been used to probe the structure-activity relationships of these inhibitors, which show potential as antibacterial agents. ...[more]
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