Ontology highlight
ABSTRACT:
SUBMITTER: Koper T
PROVIDER: S-EPMC4339722 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Koper Tomasz T Polit Agnieszka A Sobiecka-Szkatula Anna A Wegrzyn Katarzyna K Scire Andrea A Figaj Donata D Kadzinski Leszek L Zarzecka Urszula U Zurawa-Janicka Dorota D Banecki Bogdan B Lesner Adam A Tanfani Fabio F Lipinska Barbara B Skorko-Glonek Joanna J
PloS one 20150224 2
Bacterial HtrAs are proteases engaged in extracytoplasmic activities during stressful conditions and pathogenesis. A model prokaryotic HtrA (HtrA/DegP from Escherichia coli) requires activation to cleave its substrates efficiently. In the inactive state of the enzyme, one of the regulatory loops, termed LA, forms inhibitory contacts in the area of the active center. Reduction of the disulfide bond located in the middle of LA stimulates HtrA activity in vivo suggesting that this S-S bond may play ...[more]