Ontology highlight
ABSTRACT:
SUBMITTER: Xing M
PROVIDER: S-EPMC4339890 | biostudies-literature | 2015 Feb
REPOSITORIES: biostudies-literature
Xing Mengtan M Yang Mingrui M Huo Wei W Feng Feng F Wei Leizhen L Jiang Wenxia W Ning Shaokai S Yan Zhenxin Z Li Wen W Wang Qingsong Q Hou Mei M Dong Chunxia C Guo Rong R Gao Ge G Ji Jianguo J Zha Shan S Lan Li L Liang Huanhuan H Xu Dongyi D
Nature communications 20150211
Non-homologous end joining (NHEJ) is a major pathway to repair DNA double-strand breaks (DSBs), which can display different types of broken ends. However, it is unclear how NHEJ factors organize to repair diverse types of DNA breaks. Here, through systematic analysis of the human NHEJ factor interactome, we identify PAXX as a direct interactor of Ku. The crystal structure of PAXX is similar to those of XRCC4 and XLF. Importantly, PAXX-deficient cells are sensitive to DSB-causing agents. Moreover ...[more]