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IL-10 regulates adult neurogenesis by modulating ERK and STAT3 activity.

ABSTRACT: The adult subventricular zone (SVZ) contains Nestin+ progenitors that differentiate mainly into neuroblasts. Our previous data showed that interleukin-10 (IL-10) regulates SVZ adult neurogenesis by up-regulating the expression of pro-neural genes and modulating cell cycle exit. Here we addressed the specific mechanism through which IL-10 carries out its signaling on SVZ progenitors. We found that, in vitro and in vivo, IL-10 targets Nestin+ progenitors and activates the phosphorylation of ERK and STAT3. The action of IL-10 on Nestin+ progenitors is reversed by treatment with a MEK/ERK inhibitor, thus restoring neurogenesis to normal levels. Silencing STAT3 expression by lentiviral vectors also impaired neurogenesis by blocking the effects of IL-10. Our findings unveil ERK and STAT3 as effectors of IL-10 in adult SVZ neurogenesis.

SUBMITTER: Pereira L

PROVIDER: S-EPMC4340210 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature

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IL-10 regulates adult neurogenesis by modulating ERK and STAT3 activity.

Pereira Leticia L Font-Nieves Miriam M Van den Haute Chris C Baekelandt Veerle V Planas Anna M AM Pozas Esther E

Frontiers in cellular neuroscience 20150225

The adult subventricular zone (SVZ) contains Nestin+ progenitors that differentiate mainly into neuroblasts. Our previous data showed that interleukin-10 (IL-10) regulates SVZ adult neurogenesis by up-regulating the expression of pro-neural genes and modulating cell cycle exit. Here we addressed the specific mechanism through which IL-10 carries out its signaling on SVZ progenitors. We found that, in vitro and in vivo, IL-10 targets Nestin+ progenitors and activates the phosphorylation of ERK an ...[more]

PMID: 25762897

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