Ontology highlight
ABSTRACT:
SUBMITTER: Lammers T
PROVIDER: S-EPMC4340520 | biostudies-literature | 2015 Jan
REPOSITORIES: biostudies-literature
Lammers Twan T Koczera Patrick P Fokong Stanley S Gremse Felix F Ehling Josef J Vogt Michael M Pich Andrij A Storm Gert G van Zandvoort Marc M Kiessling Fabian F
Advanced functional materials 20150101 1
Efficient and safe drug delivery across the blood-brain barrier (BBB) remains to be one of the major challenges of biomedical and (nano-) pharmaceutical research. Here, we show that poly(butyl cyanoacrylate)-based microbubbles (MB), carrying ultrasmall superparamagnetic iron oxide (USPIO) nanoparticles within their shell, can be used to mediate and monitor BBB permeation. Upon exposure to transcranial ultrasound pulses, USPIO-MB are destroyed, resulting in acoustic forces inducing vessel permeab ...[more]