Ontology highlight
ABSTRACT:
SUBMITTER: Weber DA
PROVIDER: S-EPMC4340686 | biostudies-literature | 2014 Sep
REPOSITORIES: biostudies-literature
Weber D A DA Sumagin R R McCall I C IC Leoni G G Neumann P A PA Andargachew R R Brazil J C JC Medina-Contreras O O Denning T L TL Nusrat A A Parkos C A CA
Mucosal immunology 20140312 5
Neutrophil transepithelial migration (TEM) during acute inflammation is associated with mucosal injury. Using models of acute mucosal injury in vitro and in vivo, we describe a new mechanism by which neutrophils infiltrating the intestinal mucosa disrupt epithelial homeostasis. We report that junctional adhesion molecule-like protein (JAML) is cleaved from neutrophil surface by zinc metalloproteases during TEM. Neutrophil-derived soluble JAML binds to the epithelial tight junction protein coxsac ...[more]