Ontology highlight
ABSTRACT:
SUBMITTER: Metz PJ
PROVIDER: S-EPMC4340726 | biostudies-literature | 2015 Mar
REPOSITORIES: biostudies-literature
Journal of immunology (Baltimore, Md. : 1950) 20150123 5
During an immune response against a microbial pathogen, activated naive T lymphocytes give rise to effector cells that provide acute host defense and memory cells that provide long-lived immunity. It has been shown that T lymphocytes can undergo asymmetric division, enabling the daughter cells to inherit unequal amounts of fate-determining proteins and thereby acquire distinct fates from their inception. In this study, we show that the absence of the atypical protein kinase C (PKC) isoforms, PKC ...[more]