Ontology highlight
ABSTRACT:
SUBMITTER: Gu L
PROVIDER: S-EPMC4340873 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Gu Ling L Uhelski Megan L ML Anand Sanjay S Romero-Ortega Mario M Kim Young-tae YT Fuchs Perry N PN Mohanty Samarendra K SK
PloS one 20150225 2
Cumulative evidence from both humans and animals suggests that the anterior cingulate cortex (ACC) is important for pain-related perception, and thus a likely target for pain relief therapy. However, use of existing electrode based ACC stimulation has not significantly reduced pain, at least in part due to the lack of specificity and likely co-activation of both excitatory and inhibitory neurons. Herein, we report a dramatic reduction of pain behavior in transgenic mice by optogenetic stimulatio ...[more]