Dataset Information

Tumor necrosis factor-alpha polymorphism and susceptibility to multiple sclerosis in the Iranian population.

ABSTRACT: BACKGROUND:Multiple sclerosis (MS) is an immune-mediated disease of polygenic etiology. Tumor necrosis factor-? (TNF-?) microsatellite as a proinflammatory cytokine is believed to play an important role in the etiology of this disease. OBJECTIVES:The aim of this study was to investigate the association of TNF-? microsatellite sequence variation in patients with MS and its risk factor in the southern Iranian population. PATIENTS AND METHODS:This polymorphism was investigated in an Iranian population of 163 native southern people [81 patients with MS according to the poser criteria and 82 healthy controls (HC) with the same age, sex, social, ethnical and geographical features (Hormozgan and Fars provinces)]. All the controls were nonimmunological, neurological patients. All the cases and controls were chosen randomly and genotyped for polymorphism of TNF-? microsatellite. RESULTS:The frequencies of TNF-?*11 (0.25, P < 0.005) and TNF-?*10 (P < 0.005) alleles increased in patients with MS compared with controls, showing a significant difference among the studied population. CONCLUSIONS:The current study adds evidence to the association of TNF-? gene polymorphism and MS in this southern south Iranian population which is consistent with the genetic analysis of MS in Europeans (GAMES) project reports and these two alleles reported in this study may be one of the genetic risk factor for MS. Furthermore, this data can be used to build the Iranian gene bank for future studies.

SUBMITTER: Rahmanian M

PROVIDER: S-EPMC4341370 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature

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Tumor necrosis factor-alpha polymorphism and susceptibility to multiple sclerosis in the Iranian population.

Rahmanian Masoomeh M Kargar Mohammad M

Iranian Red Crescent medical journal 20141227 1

<h4>Background</h4>Multiple sclerosis (MS) is an immune-mediated disease of polygenic etiology. Tumor necrosis factor-α (TNF-α) microsatellite as a proinflammatory cytokine is believed to play an important role in the etiology of this disease.<h4>Objectives</h4>The aim of this study was to investigate the association of TNF-α microsatellite sequence variation in patients with MS and its risk factor in the southern Iranian population.<h4>Patients and methods</h4>This polymorphism was investigated ...[more]

PMID: 25763268

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Project description:The multifactorial pathogenesis of severe malaria is partly attributed to host genes, such as those encoding cytokines involved in complex inflammatory reactions, namely tumor necrosis factor-alpha (TNF-α). However, the relationship between TNF-α -308G >A gene polymorphism (rs1800629) and the severity of Plasmodium falciparum (P. falciparum) malaria remains unclear, which prompts a meta-analysis to obtain more precise estimates. The present meta-analysis aimed to better understand this correlation and provide insight into its association in populations with different ethnicities. Literature search outcomes included eight eligible articles in which TNF-α -308G >A polymorphism was determined in uncomplicated malaria (UM) and severe malaria (SM) of P. falciparum as represented in the case and control groups. Pooled odds ratios (ORs) and 95% confidence intervals (95% CIs) were estimated in standard homozygous, recessive, dominant, and codominant genetic models. Subgroup analysis was based on ethnicity, i.e., Africans and Asians. The analyses included overall and the modified outcomes; the latter was obtained without the studies that deviated from the Hardy-Weinberg Equilibrium. The significant data also underwent sensitivity treatment but not publication bias tests because the number of studies was less than ten. Interaction tests were applied to differential outcomes between the subgroups. Overall and HWE-compliant analyses showed no significant association between the TNF-α -308G >A polymorphism and susceptibility to P. falciparum SM (ORs = 1.10-1.52, 95%CIs = 0.68-2.79; Pa = 0.24-0.68). Stratification by ethnicity revealed that two significant associations were found only in the Asians favoring SM for dominant (OR = 1.95, 95% CI = 1.06-3.61, Pa = 0.03) and codominant (OR = 1.83, 95% CI = 1.15-2.92, Pa = 0.01) under the random-effects model, but not among the African populations. The two significant Asian associations were improved with a test of interaction with P-value of0.02-0.03. The significant core outcomes were robust. Results of the meta-analysis suggest that TNF-α -308G >A polymorphism might affect the risk of P. falciparum SM, particularly in individuals of Asian descent. This supports ethnicity as one of the dependent factors of the TNF-α -308G >A association with the clinical severity of malaria. Further large and well-designed genetic studies are needed to confirm this conclusion.

Dataset Information

Tumor necrosis factor-alpha polymorphism and susceptibility to multiple sclerosis in the Iranian population.

Publications

Tumor necrosis factor-alpha polymorphism and susceptibility to multiple sclerosis in the Iranian population.

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