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Successful re-treatment of a relapsed V600E mutated HCL patient with low-dose vemurafenib.

ABSTRACT: Hairy cell leukemia (HCL) is a chronic B-cell lymphoproliferative disorder that accounts for 2% of all leukemia. Recent identification of the recurrent V600E BRAF mutation in a majority of HCL patients has led some teams to evaluate the clinical potential of vemurafenib, a BRAF V600 specific inhibitor in a limited number of refractory HCL patients. Recently, we published the case of an HCL patient successfully treated with a low dose of vemurafenib. Eight months after the ending of treatment this patient relapsed. We present here the successful retreatment of this patient with a second line of vemurafenib. Our data suggest for the first time that vemurafenib at the dose of 240 mg once a day could be sufficient to maintain a complete hematological remission after an initial induction treatment with low-dose vemurafenib (2 × 240 mg) daily without inducing major toxicity.

SUBMITTER: Bailleux C

PROVIDER: S-EPMC4341463 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature

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Successful re-treatment of a relapsed V600E mutated HCL patient with low-dose vemurafenib.

Bailleux Caroline C Robert Guillaume G Ginet Clémence C Re Daniel D Thyss Antoine A Sudaka Isabelle I Peyrottes Isabelle I Hofman Paul P Auberger Patrick P Peyrade Frederic F

Oncoscience 20141226 1

Hairy cell leukemia (HCL) is a chronic B-cell lymphoproliferative disorder that accounts for 2% of all leukemia. Recent identification of the recurrent V600E BRAF mutation in a majority of HCL patients has led some teams to evaluate the clinical potential of vemurafenib, a BRAF V600 specific inhibitor in a limited number of refractory HCL patients. Recently, we published the case of an HCL patient successfully treated with a low dose of vemurafenib. Eight months after the ending of treatment thi ...[more]

PMID: 25815361

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