Protein structure. Structure and activity of tryptophan-rich TSPO proteins.
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ABSTRACT:
SUBMITTER: Guo Y
PROVIDER: S-EPMC4341906 | biostudies-literature | 2015 Jan
REPOSITORIES: biostudies-literature
Publications
Protein structure. Structure and activity of tryptophan-rich TSPO proteins.
Guo Youzhong Y Kalathur Ravi C RC Kalathur Ravi C RC Liu Qun Q Kloss Brian B Bruni Renato R Ginter Christopher C Kloppmann Edda E Rost Burkhard B Hendrickson Wayne A WA
Science (New York, N.Y.) 20150101 6221
Translocator proteins (TSPOs) bind steroids and porphyrins, and they are implicated in many human diseases, for which they serve as biomarkers and therapeutic targets. TSPOs have tryptophan-rich sequences that are highly conserved from bacteria to mammals. Here we report crystal structures for Bacillus cereus TSPO (BcTSPO) down to 1.7 Å resolution, including a complex with the benzodiazepine-like inhibitor PK11195. We also describe BcTSPO-mediated protoporphyrin IX (PpIX) reactions, including ca ...[more]
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