Ontology highlight
ABSTRACT:
SUBMITTER: Chollet R
PROVIDER: S-EPMC434192 | biostudies-literature | 2004 Jul
REPOSITORIES: biostudies-literature
Antimicrobial agents and chemotherapy 20040701 7
Multidrug resistance (MDR) in Enterobacter aerogenes can be mediated by induction of MarA, which is triggered by certain antibiotics and phenolic compounds. In this study, we identified the gene encoding RamA, a 113-amino-acid regulatory protein belonging to the AraC-XylS transcriptional activator family, in the Enterobacter aerogenes ATCC 13048 type strain and in a clinical multiresistant isolate. Overexpression of RamA induced an MDR phenotype in drug-susceptible Escherichia coli JM109 and E. ...[more]