Rhesus cytomegalovirus is similar to human cytomegalovirus in susceptibility to benzimidazole nucleosides.
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ABSTRACT:
SUBMITTER: North TW
PROVIDER: S-EPMC434194 | biostudies-literature | 2004 Jul
REPOSITORIES: biostudies-literature
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Rhesus cytomegalovirus is similar to human cytomegalovirus in susceptibility to benzimidazole nucleosides.
North Thomas W TW Sequar Getachew G Townsend Leroy B LB Drach John C JC Barry Peter A PA
Antimicrobial agents and chemotherapy 20040701 7
Rhesus and human cytomegalovirus (RhCMV and HCMV, respectively) exhibit comparable inhibition by benzimidazole nucleosides, including 2,5,6-trichloro-(1-beta-d-ribofuranosyl)benzimidazole (TCRB), and pyrrolo[2,3-d]pyrimidines. The two HCMV protein targets of TCRB, UL89 and UL56, are highly conserved with their RhCMV homologues. These data indicate that infection of rhesus macaques with RhCMV represents a useful model to test novel anti-HCMV drugs. ...[more]
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