Soluble NKG2D ligand promotes MDSC expansion and skews macrophage to the alternatively activated phenotype.
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ABSTRACT:
SUBMITTER: Xiao G
PROVIDER: S-EPMC4342005 | biostudies-literature | 2015 Feb
REPOSITORIES: biostudies-literature
Publications
Soluble NKG2D ligand promotes MDSC expansion and skews macrophage to the alternatively activated phenotype.
Xiao Gang G Wang Xuanjun X Sheng Jun J Lu Shengjun S Yu Xuezhong X Wu Jennifer D JD
Journal of hematology & oncology 20150220
Expression of surface NKG2D ligand MIC on tumor cells is deemed to stimulate NK and co-stimulate CD8 T cell anti-tumor immunity. Human cancer cells however frequently adopt a proteinase-mediated shedding strategy to generate soluble MIC (sMIC) to circumvent host immunity. High levels of sMIC have been shown to correlate with advanced disease stages in cancer patients. The underlying mechanism is currently understood as systemic downregulation of NKG2D expression on CD8 T and NK cells and perturb ...[more]
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