Ontology highlight
ABSTRACT:
SUBMITTER: Tyteca D
PROVIDER: S-EPMC4342038 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Tyteca Donatienne D Nishino Tomoya T Debaix Huguette H Van Der Smissen Patrick P N'Kuli Francisca F Hoffmann Delia D Cnops Yvette Y Rabolli Virginie V van Loo Geert G Beyaert Rudi R Huaux François F Devuyst Olivier O Courtoy Pierre J PJ
PloS one 20150226 2
The water channel aquaporin-1 (AQP1) promotes migration of many cell types. Although AQP1 is expressed in macrophages, its potential role in macrophage motility, particularly in relation with phenotype polarization, remains unknown. We here addressed these issues in peritoneal macrophages isolated from AQP1-deficient mice, either undifferentiated (M0) or stimulated with LPS to orientate towards pro-inflammatory phenotype (classical macrophage activation; M1). In non-stimulated macrophages, ablat ...[more]