Race differences in the association between multivitamin exposure and wheezing in preterm infants.
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ABSTRACT: Objective
We aimed to determine whether vitamin D exposure, as estimated by use of multivitamins, is positively or negatively associated with recurrent wheezing in infants born preterm.Study design
This prospective cohort study enrolled 300 infants, born at 28(0/7) to 34(6/7) weeks gestational age, and conducted follow-up at 3-, 6-, 9- and 12-month adjusted age.Result
Black (55.9%) and non-black (36.6%) infants experienced recurrent wheezing. Adjusted odds ratios (ORs) for the association between multivitamin exposure at 3 months and recurrent wheezing were 2.15 (95% confidence interval (CI): 0.97, 4.75) for black and 0.43 (95% CI: 0.19, 0.96) for non-black infants with an interaction by race (P=0.003). In lag-effect models, ORs were 2.69 (95% CI: 1.41, 5.14) for black and 0.50 (95% CI: 0.27, 0.92) for non-black infants.Conclusion
Differences by race were seen in association between multivitamins and wheezing; population heterogeneity should be considered when evaluating vitamin supplementation.
SUBMITTER: Hibbs AM
PROVIDER: S-EPMC4342282 | biostudies-literature | 2015 Mar
REPOSITORIES: biostudies-literature
Publications
Race differences in the association between multivitamin exposure and wheezing in preterm infants.
Hibbs A M AM Babineau D C DC Wang X X Redline S S
Journal of perinatology : official journal of the California Perinatal Association 20141002 3
<h4>Objective</h4>We aimed to determine whether vitamin D exposure, as estimated by use of multivitamins, is positively or negatively associated with recurrent wheezing in infants born preterm.<h4>Study design</h4>This prospective cohort study enrolled 300 infants, born at 28(0/7) to 34(6/7) weeks gestational age, and conducted follow-up at 3-, 6-, 9- and 12-month adjusted age.<h4>Result</h4>Black (55.9%) and non-black (36.6%) infants experienced recurrent wheezing. Adjusted odds ratios (ORs) fo ...[more]
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