Ontology highlight
ABSTRACT:
SUBMITTER: Zhu Y
PROVIDER: S-EPMC434231 | biostudies-literature | 2004 Jul
REPOSITORIES: biostudies-literature
Zhu Yonghong Y Alvarez Carmen C Doll Ronald R Kurata Hirokazu H Schebye Xiao Min XM Parry David D Lees Emma E
Molecular and cellular biology 20040701 14
To ensure proper progression through a cell cycle, checkpoints have evolved to play a surveillance role in maintaining genomic integrity. In this study, we demonstrate that loss of CDK2 activity activates an intra-S-phase checkpoint. CDK2 inhibition triggers a p53-p21 response via ATM- and ATR-dependent p53 phosphorylation at serine 15. Phosphorylation of other ATM and ATR downstream substrates, such as H2AX, NBS1, CHK1, and CHK2 is also increased. We show that during S phase when CDK2 activity ...[more]