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Pubertal development in HIV-infected African children on first-line antiretroviral therapy.


ABSTRACT: OBJECTIVES:To estimate age at attaining Tanner stages in Ugandan/Zimbabwean HIV-infected children initiating antiretroviral therapy (ART) in older childhood and investigate predictors of delayed puberty, particularly age at ART initiation. DESIGN:Observational analysis within a randomized trial. METHODS:Tanner staging was assessed every 24 weeks from 10 years of age, menarche every 12 weeks and height every 4-6 weeks. Age at attaining different Tanner stages was estimated using normal interval regression, considering predictors using multivariable regression. Growth was estimated using multilevel models with child-specific intercepts and trajectories. RESULTS:Median age at ART initiation was 9.4 years (inter-quartile range 7.8, 11.3) (n?=?582). At the first assessment, the majority (80.2%) were in Tanner stage 1; median follow-up with staging was 2.8 years. There was a strong delaying effect of older age at ART initiation on age at attaining all Tanner stages (P?

SUBMITTER: Szubert AJ 

PROVIDER: S-EPMC4342414 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature

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Pubertal development in HIV-infected African children on first-line antiretroviral therapy.

Szubert Alexander J AJ   Musiime Victor V   Bwakura-Dangarembizi Mutsawashe M   Nahirya-Ntege Patricia P   Kekitiinwa Adeodata A   Gibb Diana M DM   Nathoo Kusum K   Prendergast Andrew J AJ   Walker A Sarah AS  

AIDS (London, England) 20150301 5


<h4>Objectives</h4>To estimate age at attaining Tanner stages in Ugandan/Zimbabwean HIV-infected children initiating antiretroviral therapy (ART) in older childhood and investigate predictors of delayed puberty, particularly age at ART initiation.<h4>Design</h4>Observational analysis within a randomized trial.<h4>Methods</h4>Tanner staging was assessed every 24 weeks from 10 years of age, menarche every 12 weeks and height every 4-6 weeks. Age at attaining different Tanner stages was estimated u  ...[more]

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