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The others: our biased perspective of eukaryotic genomes.

ABSTRACT: Understanding the origin and evolution of the eukaryotic cell and the full diversity of eukaryotes is relevant to many biological disciplines. However, our current understanding of eukaryotic genomes is extremely biased, leading to a skewed view of eukaryotic biology. We argue that a phylogeny-driven initiative to cover the full eukaryotic diversity is needed to overcome this bias. We encourage the community: (i) to sequence a representative of the neglected groups available at public culture collections, (ii) to increase our culturing efforts, and (iii) to embrace single cell genomics to access organisms refractory to propagation in culture. We hope that the community will welcome this proposal, explore the approaches suggested, and join efforts to sequence the full diversity of eukaryotes.

SUBMITTER: del Campo J

PROVIDER: S-EPMC4342545 | biostudies-literature | 2014 May

REPOSITORIES: biostudies-literature

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The others: our biased perspective of eukaryotic genomes.

del Campo Javier J Sieracki Michael E ME Molestina Robert R Keeling Patrick P Massana Ramon R Ruiz-Trillo Iñaki I

Trends in ecology & evolution 20140411 5

Understanding the origin and evolution of the eukaryotic cell and the full diversity of eukaryotes is relevant to many biological disciplines. However, our current understanding of eukaryotic genomes is extremely biased, leading to a skewed view of eukaryotic biology. We argue that a phylogeny-driven initiative to cover the full eukaryotic diversity is needed to overcome this bias. We encourage the community: (i) to sequence a representative of the neglected groups available at public culture co ...[more]

PMID: 24726347

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