Ontology highlight
ABSTRACT:
SUBMITTER: Carpenter BS
PROVIDER: S-EPMC4342584 | biostudies-literature | 2015 Mar
REPOSITORIES: biostudies-literature
Carpenter Brandon S BS Barry Renee L RL Verhey Kristen J KJ Allen Benjamin L BL
Journal of cell science 20150114 5
GLI transport to the primary cilium and nucleus is required for proper Hedgehog (HH) signaling; however, the mechanisms that mediate these trafficking events are poorly understood. Kinesin-2 motor proteins regulate ciliary transport of cargo, yet their role in GLI protein function remains unexplored. To examine a role for the heterotrimeric KIF3A-KIF3B-KAP3 kinesin-2 motor complex in regulating GLI activity, we performed a series of structure-function analyses using biochemical, cell signaling a ...[more]