Ontology highlight
ABSTRACT:
SUBMITTER: Li W
PROVIDER: S-EPMC4342853 | biostudies-literature | 2015 Feb
REPOSITORIES: biostudies-literature
Li Wenge W Calder R Brent RB Mar Jessica C JC Vijg Jan J
Mutation research 20150201
Recently, great progress has been made in single cell genomics and transcriptomics. Here, we present an integrative method, termed single-cell transcriptogenomics (SCTG), in which whole exome sequencing and RNA-seq is performed concurrently on single cells. This methodology enables one to track germline and somatic variants directly from the genome to the transcriptome in individual cells. Mouse embryonic fibroblasts were treated with the powerful mutagen ethylnitrosourea (ENU) and subjected to ...[more]