Ontology highlight
ABSTRACT:
SUBMITTER: Fogle KJ
PROVIDER: S-EPMC4343116 | biostudies-literature | 2015 Feb
REPOSITORIES: biostudies-literature
Fogle Keri J KJ Baik Lisa S LS Houl Jerry H JH Tran Tri T TT Roberts Logan L Dahm Nicole A NA Cao Yu Y Zhou Ming M Holmes Todd C TC
Proceedings of the National Academy of Sciences of the United States of America 20150202 7
Blue light activation of the photoreceptor CRYPTOCHROME (CRY) evokes rapid depolarization and increased action potential firing in a subset of circadian and arousal neurons in Drosophila melanogaster. Here we show that acute arousal behavioral responses to blue light significantly differ in mutants lacking CRY, as well as mutants with disrupted opsin-based phototransduction. Light-activated CRY couples to membrane depolarization via a well conserved redox sensor of the voltage-gated potassium (K ...[more]