Age-related immune clearance of hepatitis B virus infection requires the establishment of gut microbiota.
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ABSTRACT:
SUBMITTER: Chou HH
PROVIDER: S-EPMC4343154 | biostudies-literature | 2015 Feb
REPOSITORIES: biostudies-literature
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Age-related immune clearance of hepatitis B virus infection requires the establishment of gut microbiota.
Chou Han-Hsuan HH Chien Wei-Hung WH Wu Li-Ling LL Cheng Chi-Hung CH Chung Chen-Han CH Horng Jau-Haw JH Ni Yen-Hsuan YH Tseng Hong-Tai HT Wu Dafei D Lu Xuemei X Wang Hurng-Yi HY Chen Pei-Jer PJ Chen Ding-Shinn DS
Proceedings of the National Academy of Sciences of the United States of America 20150202 7
A unique feature of hepatitis B virus (HBV) infection in humans is that viral clearance heavily depends on the age of exposure. However, the reason for this remains unclear. Here we show that gut microbiota contribute to the age dependence of HBV immunity in a hydrodynamic transfection mouse model. Although adult (12-wk-old) C3H/HeN mice cleared HBV within 6 wk postinjection (wpi), their young (6-wk-old) counterparts remained HBV-positive at 26 wpi. Sterilization of gut microbiota from 6 to 12 w ...[more]
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