Ontology highlight
ABSTRACT:
SUBMITTER: Zollmann T
PROVIDER: S-EPMC4343155 | biostudies-literature | 2015 Feb
REPOSITORIES: biostudies-literature
Zollmann Tina T Moiset Gemma G Tumulka Franz F Tampé Robert R Poolman Bert B Abele Rupert R
Proceedings of the National Academy of Sciences of the United States of America 20150202 7
ATP-binding cassette (ABC) transporters use ATP to drive solute transport across biological membranes. Members of this superfamily have crucial roles in cell physiology, and some of the transporters are linked to severe diseases. However, understanding of the transport mechanism, especially of human ABC exporters, is scarce. We reconstituted the human lysosomal polypeptide ABC transporter TAPL, expressed in Pichia pastoris, into lipid vesicles (liposomes) and performed explicit transport measure ...[more]