Ontology highlight
ABSTRACT:
SUBMITTER: Qin X
PROVIDER: S-EPMC4343256 | biostudies-literature | 2014 Jul
REPOSITORIES: biostudies-literature
Qin Xiaoyan X Zheng Chaoya C Yates John R JR Liao Lujian L
Molecular bioSystems 20140313 7
The Parkinson's disease (PD) associated gene PINK1 encodes a protein kinase that mediates the phosphorylation of multiple proteins involved in mitochondrial homeostasis. The broader downstream signaling events mediated by PINK1 kinase activity have not been well documented. We combine quantitative phosphoproteomic strategies with siRNA mediated PINK1 knock down in mammalian cells to identify alterations of phosphorylation events downstream of PINK1. Although down-regulation of PINK1 has no major ...[more]