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A multimeric MR-optical contrast agent for multimodal imaging.

ABSTRACT: We describe the design, synthesis and in vitro evaluation of a multimodal and multimeric contrast agent. The agent consists of three macrocyclic Gd(III) chelates conjugated to a fluorophore and possesses high relaxivity, water solubility, and is nontoxic. The modular synthesis is amenable for the incorporation of a variety of fluorophores to generate molecular constructs for a number of applications.

SUBMITTER: Harrison VS

PROVIDER: S-EPMC4344311 | biostudies-literature | 2014 Oct

REPOSITORIES: biostudies-literature

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A multimeric MR-optical contrast agent for multimodal imaging.

Harrison Victoria S R VS Carney Christiane E CE Macrenaris Keith W KW Meade Thomas J TJ

Chemical communications (Cambridge, England) 20141001 78

We describe the design, synthesis and in vitro evaluation of a multimodal and multimeric contrast agent. The agent consists of three macrocyclic Gd(III) chelates conjugated to a fluorophore and possesses high relaxivity, water solubility, and is nontoxic. The modular synthesis is amenable for the incorporation of a variety of fluorophores to generate molecular constructs for a number of applications. ...[more]

PMID: 25137290

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