Unknown

Dataset Information

0

Synthesis and biology of cyclic imine toxins, an emerging class of potent, globally distributed marine toxins.


ABSTRACT: From a small group of exotic compounds isolated only two decades ago, Cyclic Imine (CI) toxins have become a major class of marine toxins with global distribution. Their distinct chemical structure, biological mechanism of action, and intricate chemistry ensures that CI toxins will continue to be the subject of fascinating fundamental studies in the broad fields of chemistry, chemical biology, and toxicology. The worldwide occurrence of potent CI toxins in marine environments, their accumulation in shellfish, and chemical stability are important considerations in assessing risk factors for human health. This review article aims to provide an account of chemistry, biology, and toxicology of CI toxins from their discovery to the present day.

SUBMITTER: Stivala CE 

PROVIDER: S-EPMC4344380 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature

altmetric image

Publications

Synthesis and biology of cyclic imine toxins, an emerging class of potent, globally distributed marine toxins.

Stivala Craig E CE   Benoit Evelyne E   Aráoz Rómulo R   Servent Denis D   Novikov Alexei A   Molgó Jordi J   Zakarian Armen A  

Natural product reports 20150301 3


From a small group of exotic compounds isolated only two decades ago, Cyclic Imine (CI) toxins have become a major class of marine toxins with global distribution. Their distinct chemical structure, biological mechanism of action, and intricate chemistry ensures that CI toxins will continue to be the subject of fascinating fundamental studies in the broad fields of chemistry, chemical biology, and toxicology. The worldwide occurrence of potent CI toxins in marine environments, their accumulation  ...[more]

Similar Datasets

| S-EPMC5550345 | biostudies-literature
| S-EPMC4681848 | biostudies-other
| S-EPMC6775973 | biostudies-literature
| S-EPMC6331548 | biostudies-literature
| S-EPMC4117372 | biostudies-literature
| S-EPMC2889351 | biostudies-literature
| S-EPMC3269821 | biostudies-literature
| S-EPMC10467342 | biostudies-literature
| S-EPMC2864753 | biostudies-literature
| S-EPMC3271111 | biostudies-literature