Effect of the CCND1 A870G polymorphism on prostate cancer risk: a meta-analysis of 3,820 cases and 3,825 controls.

ABSTRACT:

Background

Cyclin D1 (CCND1) is critical in the transition of the cell cycle from the G1 to S phases, and unbalanced cell cycle regulation is a hallmark of carcinogenesis. Numerous epidemiological studies have evaluated the association between the CCND1 A870G polymorphism and the risk of prostate cancer (PCa). However, these studies have yielded conflicting results.

Methods

In the present study, the possible association above was assessed by a meta-analysis. Eligible articles were identified for the period up to July 2014. Pooled odds ratios (ORs) with 95% confidence intervals (95% CI) were appropriately derived from fixed effects or random effects models.

Results

A total of ten case-control studies, which included 3,820 cases and 3,825 controls, were identified. Over

SUBMITTER: Zheng M 

PROVIDER: S-EPMC4344796 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature