Ontology highlight
ABSTRACT:
SUBMITTER: Lu Q
PROVIDER: S-EPMC4344897 | biostudies-literature | 2015 Mar
REPOSITORIES: biostudies-literature
Lu Quanlong Q Insinna Christine C Ott Carolyn C Stauffer Jimmy J Pintado Petra A PA Rahajeng Juliati J Baxa Ulrich U Walia Vijay V Cuenca Adrian A Hwang Yoo-Seok YS Daar Ira O IO Lopes Susana S Lippincott-Schwartz Jennifer J Jackson Peter K PK Caplan Steve S Westlake Christopher J CJ
Nature cell biology 20150216 3
Membrane association with mother centriole (M-centriole) distal appendages is critical for ciliogenesis initiation. How the Rab GTPase Rab11-Rab8 cascade functions in early ciliary membrane assembly is unknown. Here, we show that the membrane shaping proteins EHD1 and EHD3, in association with the Rab11-Rab8 cascade, function in early ciliogenesis. EHD1 and EHD3 localize to preciliary membranes and the ciliary pocket. EHD-dependent membrane tubulation is essential for ciliary vesicle formation f ...[more]