A combinatorial microRNA therapeutics approach to suppressing non-small cell lung cancer.
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ABSTRACT:
SUBMITTER: Kasinski AL
PROVIDER: S-EPMC4345154 | biostudies-literature | 2015 Jul
REPOSITORIES: biostudies-literature
Publications
A combinatorial microRNA therapeutics approach to suppressing non-small cell lung cancer.
Kasinski A L AL Kelnar K K Stahlhut C C Orellana E E Zhao J J Shimer E E Dysart S S Chen X X Bader A G AG Slack F J FJ
Oncogene 20140901 27
Targeted cancer therapies, although often effective, have limited utility owing to preexisting primary or acquired secondary resistance. Consequently, agents are sometimes used in combination to simultaneously affect multiple targets. MicroRNA mimics are excellent therapeutic candidates because of their ability to repress multiple oncogenic pathways at once. Here we treated the aggressive Kras;p53 non-small cell lung cancer mouse model and demonstrated efficacy with a combination of two tumor-su ...[more]
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