Interleukin-1 as a common denominator from autoinflammatory to autoimmune disorders: premises, perils, and perspectives.
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ABSTRACT:
SUBMITTER: Lopalco G
PROVIDER: S-EPMC4345261 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
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Interleukin-1 as a common denominator from autoinflammatory to autoimmune disorders: premises, perils, and perspectives.
Lopalco Giuseppe G Cantarini Luca L Vitale Antonio A Iannone Florenzo F Anelli Maria Grazia MG Andreozzi Laura L Lapadula Giovanni G Galeazzi Mauro M Rigante Donato D
Mediators of inflammation 20150216
A complex web of dynamic relationships between innate and adaptive immunity is now evident for many autoinflammatory and autoimmune disorders, the first deriving from abnormal activation of innate immune system without any conventional danger triggers and the latter from self-/non-self-discrimination loss of tolerance, and systemic inflammation. Due to clinical and pathophysiologic similarities giving a crucial role to the multifunctional cytokine interleukin-1, the concept of autoinflammation h ...[more]
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