Proteome response at the edge of protein aggregation.
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ABSTRACT:
SUBMITTER: Sanchez de Groot N
PROVIDER: S-EPMC4345283 | biostudies-literature | 2015 Feb
REPOSITORIES: biostudies-literature
Publications
Proteome response at the edge of protein aggregation.
Sanchez de Groot Natalia N Gomes Ricardo A RA Villar-Pique Anna A Babu M Madan MM Coelho Ana Varela AV Ventura Salvador S
Open biology 20150201 2
Proteins adopt defined structures and are crucial to most cellular functions. Their misfolding and aggregation is associated with numerous degenerative human disorders such as type II diabetes, Huntington's or Alzheimer's diseases. Here, we aim to understand why cells promote the formation of protein foci. Comparison of two amyloid-β-peptide variants, mostly insoluble but differently recruited by the cell (inclusion body versus diffused), reveals small differences in cell fitness and proteome re ...[more]
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